Ultra-Humanite is a supervillain appearing in American comic books published by DC Comics. He first appeared as a recurring adversary of Superman, and was among the first villains faced by him. He was designed to be the polar opposite of Superman; while Superman is a hero with superhuman strength, Ultra-Humanite is a criminal mastermind who has a crippled body but a highly advanced intellect. The Ultra-Humanite served as Superman's nemesis until Alexei Luthor and his Silver Age counterpart Lex Luthor were introduced in the comics. The origins of the super-criminal known as the Ultra-Humanite are shrouded in mystery. Even he claims not to remember his true name or appearance and attributes his vast intellect and mental prowess to scientific experiments of an unknown nature.

Ultra-Humanite appeared in the third and final season of The CW network television series Stargirl.